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Updated: Jun 20, 2026
A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
Published on: September 16, 2022
[In vitro activity of gallic acid against Candida albicans biofilms]
Changzhong Wang1, Huijuan Cheng, Yan Guan
1School of Integrated Traditional and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China. ahwcz63@sina.com
Objective:
To investigate the effects of gallic acid against Candida albicans biofilms in vitro.
Method:
XTT reduction assay was performed to determine the effect of gallic acid on C. albicans biofilms and its adherence, and microscopic examination was conducted to assess the effect of gallic acid on morphogenesis of C. albicans biofilms; and cytotoxic assay was used to measure the adverse effects of gallic acid.
Result:
SMIC50, SMIC50 of gallic acid against C. albicans biofilms were 500, 1000 mg x L(-1), respectively; 100 mg x L(-1) and 1000 mg x L(-1) of gallic acid could inhibit the initial adherence and filamentous growth, and the agent showed poor cytotoxic activity.
Conclusion:
gallic acid displayed potent activity against C. albicans biofilm.
