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Published on: December 8, 2014
[Clostridum difficile associated disease in Latin America]
Adrián Camacho-Ortiz1, Alfredo Ponce-de-León, José Sifuentes-Osornio
1Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., México.
Few studies in Latin America address Clostridium difficile associated disease (CDAD). Antibiotic use, particularly fluoroquinolones, clindamycin, and cephalosporins, is linked to CDAD, with lower attributable mortality than in developed countries.
Area of Science:
- Infectious Diseases
- Epidemiology
- Microbiology
Context:
- Clostridium difficile associated disease (CDAD) incidence is rising globally.
- Latin America has limited research on CDAD clinical characteristics and risk factors.
- Existing studies often involve small sample sizes and retrospective designs.
Purpose:
- To review and synthesize existing literature on CDAD in Latin America.
- To identify common risk factors, clinical presentations, and treatment patterns.
- To highlight research gaps and the need for prospective studies in the region.
Summary:
- A literature review identified seven recent studies on CDAD in Latin America, primarily focusing on hospitalized adults.
- Fluoroquinolones, clindamycin, and cephalosporins were frequently associated with CDAD; metronidazole was a common treatment.
- Attributable mortality in reviewed studies was under 4%, significantly lower than reported in developed countries.
Impact:
- Identifies a critical need for more robust, prospective research on CDAD in Latin America.
- Provides a baseline understanding of CDAD epidemiology and risk factors in the region.
- Informs clinical practice and public health strategies for managing CDAD in Latin American healthcare settings.
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