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Updated: Jun 20, 2026

Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
Published on: September 9, 2021
Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes
Da-Wei Huang1, Szu-Chuan Shen, James Swi-Bea Wu
1Graduate Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan.
Abstract:
Tumor necrosis factor-alpha was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.
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