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Updated: Jun 20, 2026
Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
Synthetic viruslike particles for targeted gene delivery to alphavbeta3 integrin-presenting endothelial cells
Guy Zuber1, Monique Dontenwill, Jean-Paul Behr
1Laboratoire de Conception et Application de Molecules Bioactives, CNRS-Universite de Strasbourg UMR7199, Faculte de Pharmacie, 74, route du rhin, 67400 Illkirch, France. zuber@bioorga.u-strasbg.fr
Abstract:
Progress in the design of gene delivery systems is of utmost importance for cancer gene therapy since several physiological and intracellular barriers remain. We previously developed a technology for condensing a single gene into a single and stable globular nanometric system. In this manuscript, we have decorated the nanometric particles with cyclic RGD ligands in order to target endothelial cells. The potential of these artificial viruses as targeted gene delivery vehicles is demonstrated in vitro with alpha(v)beta(3) integrin-expressing primary endothelial cells.
