Related Experiment Video
Updated: Jun 20, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
A latent class analysis of maternal depressive symptoms over 12 years and offspring adjustment in adolescence
Susan B Campbell1, Antonio A Morgan-Lopez, Martha J Cox
1Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. sbcamp@pitt.edu
Abstract:
The authors used data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development to model patterns of maternal depressive symptoms, from the period of infants' age 1 month to adolescence (age 12 years), and then examined adolescent adjustment at age 15 years as a function of the course and severity of maternal symptoms. The authors identified 5 latent classes of symptoms in 1,357 women, while also taking into account sociodemographic measures: never depressed, stable subclinical, early decreasing, moderately elevated, and chronic. Women with few symptoms were more likely to be married, better educated, and in better physical health than were women with more elevated symptoms. At age 15 years, adolescents whose mothers were in the chronic, elevated, and stable subclinical latent classes reported more internalizing and externalizing problems and acknowledged engaging in more risky behavior than did children of never depressed mothers. Latent class differences in self-reported loneliness and dysphoria were also found. Discussion focuses on adolescent adjustment, especially among offspring whose mothers reported stable symptoms of depression across their childhoods.
Related Concept Videos
Oppositional Defiant Disorder
Diagnostic Criteria and...
Socioemotional Development during Infancy
Primary Temperament Types
Stella Chess...
Longitudinal Research
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Longitudinal Studies

