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Updated: Jun 20, 2026
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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Trends in pemphigus research over 15 years.
Y A Leshem1, L Pavlovsky, F B Mimouni
1Department of Dermatology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Summary
Pemphigus research is increasing, especially in non-dermatology journals, but high-quality evidence remains scarce. Future research should focus on improving the evidence base for this autoimmune blistering disease.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Medical Literature Analysis
Background:
- Pemphigus is a rare autoimmune blistering disease.
- It garners attention from various medical specialties.
Purpose of the Study:
- To assess the publication trends of pemphigus research over 15 years.
- To compare publications in dermatology versus non-dermatology journals.
- To evaluate the quality of the evidence in these publications.
Main Methods:
- PubMed database search for "pemphigus" from 1993-2007.
- Categorization of articles by publication type and journal type.
- Regression analysis to identify trends in publication numbers.
Main Results:
- 2032 pemphigus publications were identified.
- 61% were published in dermatology journals.
- Publication numbers increased linearly, driven by non-dermatology journals.
- While clinical trials increased, low-quality evidence (case reports, letters) also rose significantly.
- No increase in high-quality evidence was observed.
Conclusions:
- Increased contributions from non-dermatology fields are valuable.
- There is a persistent lack of high-quality evidence on pemphigus.
- Evidence-based dermatology principles are encouraged to improve future research quality.
