Related Experiment Video
Updated: Jun 20, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Approach to managing patients with nail psoriasis
1Dermatologikum Hamburg, Hamburg, Germany. kreich@dermatologikum.de
Summary
Nail psoriasis significantly impacts quality of life and may indicate psoriatic arthritis. The biologic agent infliximab demonstrates significant improvement in nail psoriasis symptoms and patient well-being.
Area of Science:
- Dermatology
- Immunology
- Rheumatology
Background:
- Psoriasis affects 2% of the population, with up to 50% experiencing concurrent nail psoriasis.
- Nail psoriasis often overlooked, causing functional impairment, pain, and psychological distress.
- Nail involvement can signal severe psoriasis or precede psoriatic arthritis (PsA).
Purpose of the Study:
- To evaluate the efficacy of biologic agents, specifically infliximab, in treating nail psoriasis.
- To assess the impact of nail psoriasis on patients' quality of life.
- To highlight the importance of effective management for nail psoriasis.
Main Methods:
- A multicenter, double-blind trial (EXPRESS study) investigated infliximab in 378 patients with moderate to severe psoriasis.
- Infliximab was administered at 5 mg/kg at specified intervals.
- Nail Psoriasis Severity Index (NAPSI) was used to evaluate treatment efficacy.
Main Results:
- Infliximab significantly improved nail psoriasis, with noticeable effects by week 10.
- Full nail clearance was achieved in 45% of patients receiving infliximab by week 50.
- Small studies indicate infliximab also improves quality of life in nail psoriasis patients.
Conclusions:
- Infliximab is an effective treatment option for nail psoriasis, improving both nail lesions and quality of life.
- Increased awareness of nail psoriasis and its impact is crucial.
- Effective management of nail psoriasis is important due to its link with PsA.
More Related Videos
Related Concept Videos
01:26Peripheral Artery Disease IV: Nursing Management
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
01:23Atherosclerosis IV: Nursing Management
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
01:24Nephrotic Syndrome III : Nursing Management
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:26Psychosis: Goals of Pharmacotherapy
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
01:28Drug Therapy
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications