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Characterization of a novel HLA-A*11 allele in a cord blood unit by sequence-based typing: HLA-A*1141

Silvia Manfroi1, Ornella Buffi, Michela Amadei

  • 1Immunogenetic Unit, Blood Transfusion Service, S. Orsola-Malpighi Hospital, Bologna, Italy.

Tissue Antigens
|August 19, 2009
PubMed

Abstract:

The new allele HLA-A*1141 differs from HLA-A*110101 at the codon 120 by a substitution at the first nucleotide (GGC to CGC).

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Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
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