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Related Concept Videos

Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...

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Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
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Published on: October 26, 2018

Cellular morphogenesis in silico.

Troy Shinbrot1, Young Chun, Carlos Caicedo-Carvajal

  • 1Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854, USA. shinbrot@soemail.rutgers.edu

Biophysical Journal
|August 19, 2009
PubMed
Summary
This summary is machine-generated.

This study models cell migration and interaction, revealing novel self-assembled patterns like segmented discs and "shish-kebab" structures. These emergent morphologies arise from unique distance-dependent cellular attraction, observed both computationally and in vitro.

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Area of Science:

  • Computational biology
  • Biophysics
  • Developmental biology

Background:

  • Cellular interactions and migration are fundamental to morphogenesis.
  • Understanding emergent patterns from simple cellular rules is a key challenge.

Purpose of the Study:

  • To develop and analyze a computational model simulating spherical cell migration and interaction.
  • To identify novel self-assembled cellular morphologies and the interaction rules governing them.

Main Methods:

  • Agent-based modeling of spherical cells with tunable attractive and repulsive interactions.
  • Simulation of cell dynamics to observe emergent collective behaviors and pattern formation.

Main Results:

  • The model successfully reproduces known cellular morphologies and discovers previously unreported patterns.
  • Novel states include a segmented disc arrangement and a "shish-kebab" structure (one cell type rings another).
  • These unique states are driven by attraction that increases with distance, unlike traditional potentials.

Conclusions:

  • Cellular self-assembly can generate complex morphologies through simple, distance-dependent interaction rules.
  • The discovered patterns have been validated in vitro, suggesting biological relevance.
  • Further research is needed to determine the in vivo significance of these self-assembled states in morphogenesis.