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Updated: Jun 20, 2026

Application of Biolayer Interferometry (BLI) for Studying Protein-Protein Interactions in Transcription
Published on: July 26, 2019
LIN28 lets BLIMP1 take the right course
1Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. mmatzuk@bcm.edu
Abstract:
The transcription factor BLIMP1 is a master regulator of primordial germ cell (PGC) specification and is suppressed by the microRNA let-7. In a recent issue of Nature, West and colleagues use a unique in vitro ES cell differentiation strategy to show that LIN28 is an essential regulator of PGC formation through inhibition of let-7 maturation and consequential induction of BLIMP1.
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