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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Updated: Jun 20, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis.

Yao-Jen Chang1, Jen-Wea Liu, Po-Cheng Lin

  • 1Department of Surgery, Buddhist Tzu Chi General Hospital Taipei Branch, Taipei, Taiwan, ROC.

Life Sciences
|August 19, 2009
PubMed
Summary
This summary is machine-generated.

Human bone marrow mesenchymal stem cells (hBMMSCs) show potential for repairing liver damage and reducing fibrosis. These stem cells may offer a new treatment option for liver cirrhosis.

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Last Updated: Jun 20, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
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Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo
10:18

Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo

Published on: September 11, 2018

Area of Science:

  • Regenerative Medicine
  • Hepatology
  • Stem Cell Biology

Background:

  • Chronic liver damage and fibrosis are significant health concerns.
  • Current treatments for liver cirrhosis have limitations.

Purpose of the Study:

  • To evaluate the efficacy of human bone marrow mesenchymal stem cells (hBMMSCs) in repairing liver damage.
  • To investigate the mechanism of fibrotic liver repair using hBMMSCs.

Main Methods:

  • Carbon tetrachloride (CCl4) was used to induce liver damage and fibrosis in a rat model.
  • GFP-labeled hBMMSCs were transplanted into the rats via the portal vein.

Main Results:

  • Transplanted hBMMSCs were detected in the liver post-transplantation.
  • Significant recovery from liver damage and reduced liver fibrosis were observed in the hBMMSC-treated group.
  • hBMMSCs expressed matrix metalloproteinases (MMPs), correlating with fibrosis reduction.

Conclusions:

  • hBMMSCs demonstrate potential for facilitating recovery from chronic liver damage.
  • hBMMSCs may effectively decrease liver fibrosis, suggesting their utility in treating liver cirrhosis.