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Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine
Patel Mohanakumara1, Nambiar Sreejayan, Vaidayanathan Priti
1Department of Crop Physiology, University of Agricultural Sciences, GKVK Campus, Bangalore 560065, India.
Abstract:
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.