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The phenylpropanoids of Aster flaccidus
Zhen-ling Liu1, Ying-qian Liu, Lei Zhao
1College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. liuzhl@lzu.edu.cn
Fitoterapia
|August 19, 2009
Summary
Two new compounds from Aster flaccidus bge were identified. Compound 2 shows significant antitumor activity against human liver carcinoma cells, while neither compound demonstrated notable anti-HIV-1 activity.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Aster flaccidus bge is a traditional medicine in northwestern China.
- Phenylpropanoids are a class of organic compounds with diverse biological activities.
Purpose of the Study:
- To isolate and identify new phenylpropanoids from Aster flaccidus bge.
- To evaluate the anti-HIV-1 and antitumor activities of the isolated compounds.
Main Methods:
- Isolation of compounds using chloroform extraction.
- Structure elucidation using 1D and 2D NMR spectroscopy and HRMS analysis.
- In vitro anti-HIV-1 and antitumor assays against BEL 7402 cell line.
Main Results:
- Two new phenylpropanoids, including a lignan, were identified: (7'R, 8S)-9'-lariciresinol-(alpha-methyl)-butanoate (1) and 5,9-dimethoxyl-7-(alpha-methyl)-butanoxyl-phenyl-2E-propenol-(alpha-methyl)-butanoate (2).
- Compounds 1 and 2 exhibited weak anti-HIV-1 activity (Therapeutic Index [TI] = 1.0-1.1).
- Compound 2 displayed significant antitumor activity against BEL 7402 cells, with IC50 values decreasing from 106.67+/-8.47 microM at 24 h to 50.51+/-6.11 microM at 72 h.
Conclusions:
- Aster flaccidus bge contains novel phenylpropanoids with potential therapeutic applications.
- Compound 2 shows promising antitumor properties warranting further investigation.
- The isolated compounds are not effective against HIV-1 at the tested concentrations.
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