Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Comparing Copy Number Variations and SNPs

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

<i>Pfcrt</i> copy number amplification detected in a <i>Plasmodium falciparum</i> outbreak.

bioRxiv : the preprint server for biology·2026

Same author

Associations between the Plasmodium falciparum genome and sickle haemoglobin identified in mild malaria cases from Ghana.

Malaria journal·2026

Same author

Genomic and epidemiological insights into the 2022-23 dengue outbreak in Oman.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026

Same author

Genomic resources for two apex avian predators from Saudi Arabia: Falco biarmicus and Falco peregrinus.

G3 (Bethesda, Md.)·2026

Same author

Epigenetic landscape of the H3K27me3 mark in macrophages transformed by Theileria annulata.

Communications biology·2026

Same author

Major features of parasite adaptation revealed by genomes of Plasmodium falciparum population samples archived for over 50 years.

Communications biology·2026

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

SnoopCGH: software for visualizing comparative genomic hybridization data.

Jacob Almagro-Garcia¹, Magnus Manske, Celine Carret

¹Wellcome Trust Sanger Institute, Hinxton, The Weatherall Institute of Molecular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. jg10@sanger.ac.uk

Bioinformatics (Oxford, England)

|August 19, 2009

Summary

This summary is machine-generated.

This study introduces SnoopCGH, a software tool designed for analyzing genomic structural variations (SVs) from array comparative genomic hybridization (CGH) data. The tool aids in visualizing and summarizing complex genomic data for efficient SV identification and analysis.

More Related Videos

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Related Experiment Videos

Last Updated: Jun 20, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Area of Science:

Genomics
Bioinformatics
Computational Biology

Background:

Array-based comparative genomic hybridization (CGH) is crucial for identifying genomic structural variations (SVs).
Effective visualization and summarization of array CGH data are essential for SV analysis across multiple samples.

Purpose of the Study:

To develop a software tool for the analysis of structural variants (SVs) using array CGH data.
To provide a method for visualizing and summarizing array CGH outputs for SV identification.

Main Methods:

Developed a Java-based software tool named SnoopCGH.
The tool processes data from array CGH technologies.
The software is also compatible with short-read sequencing data.

Main Results:

SnoopCGH facilitates the discovery and validation of genomic structural variations.
The software aids in the visualization and summarization of array CGH data.
The tool supports analysis across multiple samples for comprehensive SV identification.

Conclusions:

SnoopCGH is a valuable software tool for structural variant analysis.
The tool enhances the interpretation of array CGH and short-read sequencing data for genomic variation studies.