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Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case
Katharine R Hibbard1, Arthur Propst, Daniel E Frank
1correspondence and M.D., 4333 Chemin de la Cote Ste-Catherine, Montreal, Quebec H3T 1E4. katharine.hibbard@mail.mcgill.ca
Background:
Constipation is an exceedingly common side effect of treatment with clozapine. In rare cases, this side effect has resulted in fatal complications.
Objective:
The authors review the literature on fatal complications of clozapine-related constipation and bowel obstruction.
Method:
The authors provide two new case reports of patients who died of similar causes.
Results:
There were seven reports of deaths from clozapine-related bowel obstruction in the literature, with the most common mechanisms of death being severe impaction leading either to feculent vomiting or bowel necrosis.
Discussion:
The discussion outlines potential mechanisms and management of clozapine-related constipation.
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