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Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012
Pseudolipomatosis affects specimens from endometrial biopsies.
Suvarna A Deshmukh-Rane1, Mark Li-cheng Wu
1Department of Pathology and Laboratory Medicine, University of California Irvine Medical Center, Orange, CA 92868, USA.
American Journal of Clinical Pathology
|August 19, 2009
Summary
Pseudolipomatosis, clear vacuoles in tissue, is common in endometrial biopsies. This finding, often resembling fat, is unlikely to indicate uterine perforation and should not be misdiagnosed.
Area of Science:
- Pathology
- Gastroenterology
- Gynecology
Background:
- Pseudolipomatosis involves optically clear vacuoles artifactually contaminating specimens.
- It commonly affects the gastrointestinal tract and resembles adult white fat.
- This phenomenon has not been previously reported in endometrial tissue.
Purpose of the Study:
- To determine the prevalence of endometrial pseudolipomatosis.
- To investigate the relationship between endometrial pseudolipomatosis and uterine perforation.
Main Methods:
- Retrospective review of 50 consecutive endometrial biopsy specimens.
- Classification of pseudolipomatosis based on vacuole size variation (Group A or B).
- Assessment for presence of extrauterine tissue and clinical follow-up for perforation.
Main Results:
- All 50 endometrial biopsy specimens exhibited pseudolipomatosis (Group B).
- No specimens contained extrauterine adipocytes suggestive of perforation.
- Clinical follow-up indicated no evidence of perforation in the patients studied.
Conclusions:
- Endometrial pseudolipomatosis is a common finding in endometrial biopsies.
- It is likely an artifact and not indicative of uterine perforation.
- Awareness is crucial to prevent misdiagnosis of uterine perforation.
