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CD20-targeted therapy: a breakthrough in the treatment of non-Hodgkin's lymphoma

T van Meerten1, A Hagenbeek

  • 1Department of Haematology, University Medical Centre Utrecht, Utrecht, the Netherlands.

The Netherlands Journal of Medicine
|August 19, 2009
PubMed

Targeting the CD20 antigen on B lymphocytes with the monoclonal antibody rituximab has greatly improved the outcome of patients with B-cell malignancies. Despite the success of rituximab, resistance occurs in about half of the patients, resulting in non-response to treatment or early relapse of the original disease. A better understanding of the mechanism of rituximab resistance has lead to the development of novel, improved anti-CD20 antibodies. This review describes the development of CD20-targeted therapy from its historical background towards the next generation of anti-CD20 monoclonal antibodies and explains new strategies to overcome resistance.

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