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Updated: Jun 20, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic
Yayoi Matsuo1, Kenjiro Kamezaki, Shoichiro Takeishi
1Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka.
Abstract:
We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplantation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.
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