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Related Experiment Video

Updated: Jun 20, 2026

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
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Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations

Published on: June 23, 2022

Controlled detection in composite nanoresonant array for surface plasmon resonance sensing.

Lin Pang1, Haiping M Chen, Lilin Wang

  • 1Department of Electrical of Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. lpang@ece.ucsd.edu

Optics Express
|August 19, 2009
PubMed
Summary
This summary is machine-generated.

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A novel nanostructure enhances biorecognition sensitivity by coupling plasmon waves. This cost-effective sensor shows improved detection limits for biosensing applications.

Area of Science:

  • Plasmonics
  • Nanotechnology
  • Biosensing

Background:

  • Surface plasmon resonance (SPR) is a powerful label-free biosensing technique.
  • Enhancing sensitivity in SPR sensors is crucial for detecting low-concentration analytes.
  • Existing nanohole array sensors have limitations in sensitivity and fabrication.

Purpose of the Study:

  • To develop a composite nanoresonant structure for enhanced sensitivity in biorecognition reactions.
  • To investigate the coupling between localized resonance and propagating surface plasmon polariton waves.
  • To demonstrate the improved limit of detection and capabilities of the proposed sensor.

Main Methods:

  • Fabrication of a metallodielectric nanostructure using holographic lithography and oblique metallic deposition.

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Last Updated: Jun 20, 2026

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
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Published on: June 23, 2022

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  • Integration of the nanostructure with microfluidic channels.
  • Examination of biorecognition reactions and analysis of temperature influence on binding affinity.

    • Main Results:

    • The composite nanoresonant structure demonstrated pronounced improvement in the limit of detection compared to conventional nanohole array sensors.
    • The sensor showed effective performance in biorecognition reactions.
    • The influence of temperature on binding affinity and the effectiveness of a control channel were successfully investigated.

    Conclusions:

    • The developed composite nanoresonant structure offers a cost-effective, large-area, and reconfigurable platform for enhanced biosensing.
    • The sensor exhibits superior sensitivity for biorecognition reactions, paving the way for advanced diagnostic tools.
    • The study highlights the potential of coupled plasmonic resonances for next-generation biosensor development.