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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

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Well-differentiated and dedifferentiated liposarcomas.

Jean-Michel Coindre¹, Florence Pédeutour, Alain Aurias

¹Department of Pathology and INSERM U916, Institut Bergonié, Bordeaux, France. coindre@bergonie.org

Virchows Archiv : an International Journal of Pathology

|August 19, 2009

Summary

Atypical lipomatous tumor (ALT) and well-differentiated liposarcoma (WDLPS) share a key genetic alteration with dedifferentiated liposarcoma (DDLPS), involving MDM2 gene amplification. This review covers their shared molecular pathology, diagnosis, and prognosis.

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Area of Science:

Oncology
Molecular Pathology
Genetics

Background:

Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) are common soft tissue tumors.
Both share a characteristic genetic abnormality: amplification at 12q14-15, including the MDM2 gene.

Purpose of the Study:

To provide a comprehensive review of ALT-WDLPS and DDLPS.
To discuss their shared molecular pathology, clinical and imaging features, histopathology, diagnostic tools, and prognosis.

Main Methods:

Literature review focusing on molecular pathology, clinical presentation, imaging, histopathology, diagnostics, and prognosis.
Synthesis of current knowledge on these liposarcoma subtypes.

Main Results:

ALT-WDLPS and DDLPS are the most frequent liposarcomas.
A consistent genetic profile with 12q14-15 amplification (MDM2) is observed in both.
The review consolidates information on their multifaceted aspects.

Conclusions:

Understanding the shared genetic basis is crucial for diagnosing and managing ALT-WDLPS and DDLPS.
Integrated knowledge of molecular, clinical, and pathological features aids in prognosis assessment.
Advances in diagnostic tools are improving patient care for these frequent liposarcomas.