Related Experiment Video
Updated: Jun 20, 2026

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
Published on: September 7, 2010
Toll-like receptors in neurodegeneration
1Medical Biotechnology Center, University of Southern Denmark, Winsloewparken 25, 5000, Odense C, Denmark. towens@health.sdu.dk
Abstract:
Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration. Accompanying roles for infection and inflammation, involvement in clinical neurodegenerative disorders, and heterogeneity of glial response are discussed. A "strength of signal" hypothesis is advanced in an attempt to reconcile evolutionarily selected and therefore likely beneficial effects of TLR signaling in the nervous system with capability for neurotoxocity and gliotoxicity.
Related Concept Videos
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Alzheimer Disease ll: Pathophysiology
Neural Regulation
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression

