Related Experiment Video
Updated: Feb 6, 2026

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults
Published on: December 9, 2014
IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I
1Center for Molecular Immunology & Infectious Disease, Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, PA 16802, USA. axa45@psu.edu
Abstract:
The signals that regulate T-cell activation have been studied for some time. We know that upon interaction with antigen/MHC complex, the TCR triggers the activation of a number of kinases, including tyrosine and serine/threonine kinases. The Tec family kinase IL-2- inducible T-cell kinase (ITK) plays a role in this response, but the signaling pathways that ITK regulates are less well known. Even less known are the binding partners and substrates of ITK. A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed.
Related Concept Videos
Protein Kinases and Phosphatases
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein Kinases and Phosphatases
Receptor Tyrosine Kinases
Induced Pluripotent Stem Cells
Induced Pluripotent Stem Cells
Somatic...
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H

