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Published on: January 18, 2018

Optimal management of hypertension in patients with ischemic heart disease

Debabrata Mukherjee1, Charles L Campbell

  • 1Gill Heart Institute and the Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky 40536-0200, USA. Mukherjee@uky.edu

Cardiovascular & Hematological Agents in Medicinal Chemistry
|August 20, 2009
PubMed

Insights

Managing hypertension in patients with ischemic heart disease (IHD) involves balancing oxygen supply and demand. This review guides the use of antihypertensive drugs for IHD, acute coronary syndromes, and heart failure, emphasizing blood pressure control.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension is a significant risk factor for cardiovascular disease (CVD), including myocardial infarction (MI) and stroke.
  • A strong association exists between hypertension and ischemic heart disease (IHD).
  • Patients with hypertension and heart failure represent a high-risk group requiring careful management.

Purpose of the Study:

  • To review current guidelines on antihypertensive drug selection for patients with established IHD, acute coronary syndromes, MI, and heart failure.
  • To identify antihypertensive agents beneficial for these patient populations.
  • To highlight drug classes that should be avoided in hypertensive patients with IHD and heart failure.

Main Methods:

  • Review of current clinical guidelines.
  • Analysis of evidence supporting the use and avoidance of specific antihypertensive drug classes.
  • Synthesis of recommendations for managing hypertension in specific cardiovascular conditions.

Main Results:

  • Specific antihypertensive drug classes are recommended for patients with IHD, acute coronary syndromes, MI, and heart failure.
  • Certain antihypertensive agents should be avoided in these high-risk patient groups.
  • Effective blood pressure control is the primary goal, regardless of the specific agent used.

Conclusions:

  • Appropriate selection of antihypertensive agents is crucial for managing patients with IHD and heart failure.
  • Adherence to current guidelines ensures optimal treatment outcomes.
  • Achieving adequate blood pressure control is paramount in reducing cardiovascular adverse events.

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