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A case of S-100-positive juvenile xanthogranuloma: a longitudinal observation
Yosuke Yamamoto1, Masafumi Kadota, Youichi Nishimura
1Department of Dermatology, Toyooka Hospital, Tobera, Toyooka, Hyogo, Japan. yamamotoy2@gmail.com
Abstract:
We present the case of a 9-month-old boy with yellow-brown papules that gradually increased in number over a period of 6 months without systemic involvement. Our case was clinicopathologically diagnosed as S-100-positive juvenile xanthogranuloma, and longitudinal observation revealed that strong S-100 reactivity disappeared in parallel with maturation of the lesions within 2 years after the initial diagnosis. These findings add to the complexity in cells of origin of this disorder.