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Updated: Jun 20, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

Postnatal development of arteriovenous malformations.

Rosalind L Jeffree¹, Marcus A Stoodley

¹Australian School of Advanced Medicine, Macquarie University, and Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, NSW, Australia.

Pediatric Neurosurgery

|August 20, 2009

Summary

Arteriovenous malformations (AVMs) may develop after birth, not just be congenital. This study suggests postnatal development and growth, potentially triggered by factors like shear stress, leading to symptoms.

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Area of Science:

Neurology
Vascular Biology
Developmental Biology

Background:

Arteriovenous malformations (AVMs) are typically considered congenital, yet manifest in adolescence/adulthood.
This study investigates AVM development from birth to clinical presentation.

Observation:

A retrospective review of 34 patients under 25 with AVMs or intracerebral hemorrhage was conducted.
Three pediatric cases showed de novo AVM appearance post-hemorrhage with normal initial angiography.
One case demonstrated AVM recurrence after surgical resection.

Findings:

The study hypothesizes postnatal AVM development and growth during childhood/early adulthood.
Shear stress on endothelial cells in arteriovenous fistulas is proposed as a growth trigger.
Venous hypertension is considered a potential, though less likely, stimulus.

Implications:

AVMs may have a postnatal developmental trajectory, challenging the congenital-only model.
Understanding developmental triggers could inform future AVM prevention or treatment strategies.
Early detection and monitoring may be crucial given potential symptom onset from early development.