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Related Experiment Video

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Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response
09:45

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Published on: August 10, 2017

Positive selection for elevated gene expression noise in yeast.

Zhihua Zhang1, Wenfeng Qian, Jianzhi Zhang

  • 1Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Molecular Systems Biology
|August 20, 2009
PubMed
Summary
This summary is machine-generated.

Natural selection usually reduces gene expression noise. However, this study shows yeast plasma-membrane transporters exhibit elevated expression noise, suggesting it can be advantageous and drive evolution.

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Area of Science:

  • Genetics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Natural selection typically minimizes gene expression noise for essential genes.
  • Elevated expression noise can be advantageous under specific conditions.

Purpose of the Study:

  • To investigate whether elevated gene expression noise is subject to positive selection in yeast.
  • To explore the role of expression noise in the evolution of gene expression.

Main Methods:

  • Genome-wide analysis of yeast gene expression noise data.
  • Development and simulation of a theoretical model for expression noise evolution.
  • Statistical analysis controlling for confounding factors.

Main Results:

  • Plasma-membrane transporters in yeast show significantly elevated expression noise.
  • Elevated noise increases the evolvability of gene expression by facilitating beneficial mutations.
  • Genes with higher noise exhibit greater divergence across yeast strains and species.

Conclusions:

  • Elevated expression noise in yeast plasma-membrane transporters is advantageous and positively selected.
  • Increased gene expression noise facilitates adaptive evolution of gene expression.
  • Expression noise is a key factor in the evolutionary dynamics of gene expression.