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Updated: Jun 20, 2026
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High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology
Published on: May 18, 2022
Clinical and histopathological aspects in otomastoiditis
Cristina Popescu1, Elena Ioniţă, Carmen Aurelia Mogoantă
1Otorhinolaryngology Clinic, Emergency County Hospital, Craiova, Romania. cristina.popescu25@yahoo.com
Summary
This study correlates clinical otomastoiditis with histopathology, finding cholesteatoma in 41.10% of cases requiring surgery. Chronic inflammation with T-lymphocytes and macrophages indicates a cellular immune response.
Area of Science:
- Otolaryngology
- Pathology
- Immunology
Background:
- Otomastoiditis, an inflammation of the middle ear and mastoid, presents varied clinical and histopathological features.
- Understanding these correlations is crucial for effective diagnosis and treatment strategies.
Purpose of the Study:
- To establish correlations between clinical manifestations and histopathological changes in otomastoiditis.
- To analyze surgical treatment outcomes and histopathological findings in a cohort of patients.
Main Methods:
- Retrospective clinical and statistical study of 146 otomastoiditis patients (2003-2007).
- Surgical procedures included total or partial petromastoidian evidation.
- Histopathological analysis involved classical histology (H&E, Van Gieson) and immunohistochemistry.
Main Results:
- Chronic otomastoiditis was observed in 97.95% of patients, often linked to prior middle ear infections.
- Cholesteatoma was the most frequent histopathological diagnosis (41.10%), necessitating surgical intervention.
- Histopathology revealed epithelial necrosis, hypertrophy, hyperplasia, and chronic inflammatory infiltrate (lymphocytes, plasmocytes, macrophages) in the chorion.
Conclusions:
- A significant correlation exists between clinical presentation and histopathological findings in otomastoiditis.
- Cholesteatoma is a primary driver for surgical intervention in these cases.
- The presence of T-lymphocytes and macrophages confirms a predominantly cellular immune response in the middle ear mucosa.
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