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The Key Events Dose-Response Framework: its potential for application to foodborne pathogenic microorganisms
Robert L Buchanan1, Arie H Havelaar, Mary Alice Smith
1Center for Food Safety and Security Systems, University of Maryland, College Park, MD, USA.
Critical Reviews in Food Science and Nutrition
|August 20, 2009
Summary
The Key Events Dose-Response Framework (KEDRF) offers a structured method to analyze dose-response relationships for pathogenic microorganisms. This framework aids in identifying knowledge gaps to improve food safety assessments.
Area of Science:
- Food safety
- Microbiology
- Risk assessment
Background:
- Dose-response relationships are crucial for understanding pathogen risks.
- Existing data often requires assumptions due to knowledge gaps.
- The Key Events Dose-Response Framework (KEDRF) provides a structured approach.
Purpose of the Study:
- To explore the application of the KEDRF to pathogenic microorganisms.
- To use fetal listeriosis from L. monocytogenes as a case study.
- To evaluate host and pathogen factors influencing dose-response.
Main Methods:
- Systematic consideration of biological events from ingestion to endpoint.
- Analysis of dose (organism number), pathogen factors (virulence), and host defenses (immune response).
- Application of the KEDRF to a foodborne listeriosis model.
Main Results:
- The KEDRF provides a useful structure for evaluating complex host-pathogen interactions.
- The framework aids in identifying and quantifying sources of variability.
- It supports a more robust scientific basis for food safety decisions.
Conclusions:
- The KEDRF is a valuable tool for analyzing dose-response relationships in foodborne pathogens.
- It helps reduce reliance on assumptions by highlighting knowledge gaps.
- Implementing the KEDRF strengthens the scientific foundation for food safety decision-making.
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