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Preparation of Expanded Chitin Foams and their Use in the Removal of Aqueous Copper
Published on: February 27, 2021
Characterization of chitin-metal silicates as binding superdisintegrants
Iyad Rashid1, Nidal Daraghmeh, Mayyas Al-Remawi
1The Jordanian Pharmaceutical Manufacturing Co., PO Box 94, Naor 11710, Jordan.
Journal of Pharmaceutical Sciences
|August 20, 2009
Summary
Processing chitin with metal silicates offers pharmaceutical advantages over silicon dioxide. This method yields nonhygroscopic, compactable formulations with improved drug binding and disintegration properties.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Biopolymers
Background:
- Chitin is a biopolymer with potential pharmaceutical applications.
- Traditional processing of chitin with silicon dioxide presents industrial challenges.
- Alternative processing methods are needed to enhance chitin's formulation properties.
Purpose of the Study:
- To investigate the coprecipitation of metal silicates onto chitin particles.
- To evaluate the impact of metal silicates on chitin's physical properties for pharmaceutical formulations.
- To assess the suitability of chitin-metal silicates for formulating poorly compressible drugs.
Main Methods:
- Coprecipitation of aluminum, magnesium, or calcium silicates onto chitin particles.
- Evaluation of nonhygroscopic, compactable, and disintegrable properties of the resulting composites.
- Investigation of disintegration and hardness parameters, independent of particle size.
- Analysis of capillary action's role in water uptake and disintegration.
Main Results:
- Chitin coprocessed with aluminum, magnesium, or calcium silicates produced nonhygroscopic, highly compactable, and disintegrable materials.
- Compaction and compression properties were dependent on the specific metal silicate used.
- Disintegration and hardness were found to be independent of particle size.
- Capillary action was identified as a key factor in water uptake and disintegration.
Conclusions:
- Metal silicate coprecipitation offers an advantageous alternative to silicon dioxide for processing chitin in pharmaceutical formulations.
- Chitin-metal silicates exhibit excellent compaction and disintegration properties, beneficial for pharmaceutical applications.
- These materials are particularly useful for formulating poorly compressible and/or highly nonpolar drugs.
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