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Related Concept Videos

Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

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Updated: Jun 20, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
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Postherpetic neuralgia in the elderly.

R W Johnson1, J McElhaney

  • 1University of Bristol, Bristol, UK. r.w.johnson@bris.ac.uk

International Journal of Clinical Practice
|August 21, 2009
PubMed
Summary

Postherpetic neuralgia (PHN) is a common complication of shingles, especially in the elderly. Vaccination against varicella zoster virus may prevent shingles and reduce PHN incidence and severity.

Area of Science:

  • Geriatrics
  • Infectious Diseases
  • Neurology

Background:

  • Postherpetic neuralgia (PHN) is the most frequent complication of herpes zoster (HZ), or shingles.
  • The elderly are most commonly and severely affected by PHN, which significantly impacts quality of life.

Purpose of the Study:

  • To review the epidemiology, clinical features, and management of PHN in the elderly.
  • To explore the potential of varicella zoster virus (VZV) vaccination in preventing HZ and subsequent PHN.

Main Methods:

  • Literature review focusing on PHN in elderly populations.
  • Analysis of VZV vaccination strategies for HZ prevention.

Main Results:

  • PHN is characterized by persistent pain after HZ rash resolution, often resistant to treatment.

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  • The elderly experience higher incidence and severity of PHN.
  • Conclusions:

    • PHN poses a significant clinical challenge, particularly in older adults.
    • Preventive strategies, including VZV vaccination, are crucial for reducing the burden of HZ and PHN.