Related Experiment Video
Updated: Jun 20, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
Published on: January 17, 2011
The place of premedication in pediatric practice
Abraham Rosenbaum1, Zeev N Kain, Peter Larsson
1Department of Anesthesiology & Perioperative Care, University of California Irvine, Orange, CA, USA.
Insights
Pediatric premedication with sedative drugs aims to reduce anesthesia-related psychological trauma. However, cultural variations and the long-term impact of the administration process complicate evidence-based conclusions.
Area of Science:
- Anesthesiology
- Pediatric Psychology
- Healthcare Management
Background:
- Sedative premedication in children is debated for its effectiveness in minimizing psychological trauma associated with anesthesia and surgery.
- Reaching evidence-based conclusions is challenging due to confounding factors like cultural variations in expectations and responses.
- The scope of hospital-related distress extends beyond anesthetic induction, encompassing the entire patient journey.
Purpose of the Study:
- To critically evaluate the practice of pediatric premedication.
- To highlight diverse approaches to premedication in different global settings.
- To encourage a re-evaluation of routine pediatric premedication versus selective use.
Main Methods:
- This article presents a pro-con discussion of pediatric premedication strategies.
- It incorporates insights from actual clinical practice experiences.
- It contrasts historical universal practices with current selective approaches.
Main Results:
- Significant variability exists in parental and child expectations and responses to premedication across different cultures and hospital systems.
- The administration of premedication, especially when resisted by the child, can cause trauma not always captured in formal studies.
- Attitudes among healthcare professionals and parents towards routine pediatric premedication are diverse and often strongly held.
Conclusions:
- The effectiveness and appropriateness of pediatric premedication are complex and influenced by numerous factors beyond the immediate anesthetic induction.
- Cultural context and individual patient experiences, including the act of administration, are critical considerations.
- A move towards more selective premedication practices in many centers warrants critical re-evaluation of historical universal approaches.
Abstract:
Behind the multiple arguments for and against the use of premedication, sedative drugs in children is a noble principle that of minimizing psychological trauma related to anesthesia and surgery. However, several confounding factors make it very difficult to reach didactic evidence-based conclusions. One of the key confounding issues is that the nature of expectations and responses for both parent and child vary greatly in different environments around the world. Studies applicable to one culture and to one hospital system (albeit multicultural) may not apply elsewhere. Moreover, the study of hospital-related distress begins at the start of the patient's journey and ends long after hospital discharge; it cannot be focused completely on just the moment of anesthetic induction. Taking an example from actual practice experience, the trauma caused by the actual giving of a premedication to a child who absolutely does not want it and may struggle may not be recorded in a study but could form a significant component of overall effect and later psychological pathology. Clearly, attitudes by health professionals and parents to the practice of routine pediatric premedication, vary considerably, often provoking strong opinions. In this pro-con article we highlight two very different approaches to premedication. It is hoped that this helps the reader to critically re-evaluate a practice, which was universal historically and now in many centers is more selective.
Related Concept Videos
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug Delivery: Enteral Route
Drugs in...

