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Related Experiment Video

Updated: Jun 20, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

New objective evaluation method for functional bowel disorder using video capsule endoscopy.

Masanao Nakamura¹, Yasumasa Niwa, Makoto Yagihashi

¹Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society

|August 21, 2009

Summary

Video capsule endoscopy (VCE) objectively evaluated bowel movements in irritable bowel syndrome (IBS) patients versus healthy volunteers. Healthy individuals showed more periodic changes in luminal movement volume than IBS patients.

Related Experiment Videos

Last Updated: Jun 20, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Area of Science:

Gastroenterology
Medical Imaging
Functional Bowel Disorders

Background:

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder.
Objective evaluation of bowel movements in IBS patients remains challenging.

Purpose of the Study:

To objectively assess bowel movements in IBS patients using video capsule endoscopy (VCE).
To compare VCE findings between IBS patients and healthy volunteers.

Main Methods:

Nine healthy volunteers and five IBS patients underwent VCE.
Analysis focused on luminal movement changes by quantifying low brightness area (LBA) pixels in VCE images.
Comparison of LBA volume and temporal changes between groups.

Main Results:

No significant difference in the frequency of LBA was observed between groups.
Healthy individuals exhibited a trend towards larger average LBA volume compared to IBS patients.
Periodic changes in LBA volume over time were detected in 88.9% of healthy individuals versus 40.0% of IBS patients.

Conclusions:

VCE offers a potential new method for objectively evaluating functional bowel disorders.
The study demonstrated objective differences in bowel movement patterns between IBS patients and healthy controls.