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Acute hepatitis due to brivudin: a case report.

Alexandre Mottu¹, Laura Rubbia-Brandt, Florian Bihl

¹General Internal Medicine, University Hospitals, Geneva, Switzerland.

Journal of Hepatology

|August 21, 2009

Summary

Brivudin, used for herpetic infections, can cause acute immunoallergic hepatitis. This case, confirmed by liver biopsy, highlights a rare but serious side effect.

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Area of Science:

Hepatology
Pharmacology
Immunology

Background:

Brivudin is approved in Europe for treating herpetic infections.
Previous multicenter trials indicated a favorable safety profile, with rare transient liver enzyme elevations.

Observation:

This report details a case of acute hepatitis potentially induced by brivudin.
Liver biopsy was performed to investigate the hepatitis.

Findings:

The liver biopsy revealed acute liver injury with a predominantly cytolytic pattern.
Features observed were suggestive of drug-induced immunoallergic hepatitis.
Alanine aminotransferase (ALT) levels normalized within weeks after discontinuation.

Implications:

This is the first documented case of acute immunoallergic hepatitis attributed to brivudin.
Highlights the importance of considering brivudin as a potential cause of drug-induced liver injury.
May inform clinical practice regarding patient monitoring during brivudin therapy.