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09:16
Orthotopic Small Bowel Transplantation in Rats
Published on: November 6, 2012
[Intestinal failure: from adaptation to transplantation].
1Service de Gastroentérologie et Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Labellisé Pour les Maladies Intestinales Rares et la Transplantation Intestinale, Pôle des Maladies de l'Appareil Digestif, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, 92110 Clichy, France. bernard.messing@bjn.aphp.fr
Gastroenterologie Clinique Et Biologique
|August 21, 2009
Summary
Optimised Home Parenteral Nutrition remains the standard for chronic intestinal failure. Advances in therapies like intestinal trophic factors, surgery, and transplantation offer improved management and outcomes for intestinal failure patients.
Area of Science:
- Gastroenterology and Hepatology
- Surgical Sciences
- Transplant Surgery
Context:
- Chronic Intestinal Failure (CIF) management relies on optimized Home Parenteral Nutrition (HPN) as the current gold standard.
- Recognition of CIF's diverse manifestations is crucial for effective HPN-associated treatment strategies.
- Significant progress in HPN over 35 years necessitates a broader approach to associated therapies.
Purpose:
- To highlight the evolving landscape of intestinal failure treatment beyond HPN.
- To emphasize the need for a comprehensive understanding and management of chronic intestinal failure.
- To discuss the role of advanced therapies in modifying the prognosis of irreversible intestinal failure.
Summary:
- Optimized Home Parenteral Nutrition (HPN) is the established treatment for chronic intestinal failure.
- Emerging therapies include intestinal trophic factors (e.g., growth hormone, GLP-2), rehabilitative surgery, and reconstructive surgery like intestinal transplantation.
- Intestinal transplantation is a mature option for HPN failure, particularly when liver disease is present, with preemptive indications for high-risk patients.
Impact:
- Future management of intestinal failure will integrate multiple therapies to improve remnant gut absorption and patient outcomes.
- Further research is needed for rare conditions like chronic intestinal pseudo-obstruction, mirroring progress in short bowel syndrome.
- Establishment of reference centers with expertise in the full spectrum of medicosurgical therapies is vital for optimizing intestinal failure patient care.
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