Related Experiment Video
Updated: Jun 20, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Heat-related mortality: a review and exploration of heterogeneity
1Public & Environmental Health Research Unit, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. shakoor.hajat@lshtm.ac.uk
Abstract:
Although rapid response capacity has been instituted in many cities following recent catastrophic heatwave events, the recognition that theoretically preventable heat-related deaths may occur throughout the summer has provoked much less response. This essay reviews published estimates of the general summertime temperature-mortality relationship characterised in different settings around the world. A random-effects meta-regression is applied to the estimates in relation to a number of standardised city-level characteristics of demography, economy and climate. Heat thresholds were generally higher in communities closer to the equator, suggesting some population adaptation. In almost half of the locations, the risk of mortality increased by between 1% and 3% per 1 degrees C change in high temperature. Increasing population density, decreasing city gross domestic product and increasing percentage of people aged 65 or more were all independently associated with an increase in the heat slope. Improved care of older people, residential architecture and urban planning measures to reduce high temperatures in densely populated areas are likely to play a key role alongside targeted heat-health warning systems in reducing future heat burdens.
Related Concept Videos
Factors Affecting Body Temperature
Factors may include:
Homeostatic Imbalances in Body Temperature
Bias in Epidemiological Studies
Decreased Body Temperature
Comparing the Survival Analysis of Two or More Groups
Requirements for Human Life
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
