Cell encapsules with tunable transport and mechanical properties
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Updated: Jun 20, 2026
Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
Published on: October 26, 2009
Dawei Luo1, Srinivasa Rao Pullela, Manuel Marquez
1Artie McFerrin, Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843-3122, USA and INEST (Interdisciplinary Network of Emerging Science and Technologies) Group Postgraduate Program, Philip Morris USA, Richmond, Virginia 23234, USA.
Abstract:
We utilized a microfluidic device with hydrodynamic flow focusing geometry to produce uniform agarose droplets in the range of 50 to 110 mum. The transport property of the thermally gelled particles was tailored by layer-by-layer (LBL) polyelectrolytes coating on the surface and was measured via the release rates of Rhodamine B. The mechanical strength of the capsules was further enhanced by a coating of silica nano-particles in addition to polyelectrolyte coatings. We demonstrated that yeast cells can be successfully encapsulated into agarose capsules.
