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Published on: March 3, 2023
Messages from the Aalst Allergy Study
Dirk Van Gysel1, Elke Govaere, Katia M C Verhamme
1Department of Pediatrics, O.L.Vrouw Hospital, Aalst, Belgium. dirk.van.gysel@olvz-aalst.be
Insights
This Belgian study found that age, gender, BMI, bedroom environment, and pet exposure significantly influence allergic sensitization and symptoms in children. These factors highlight the complexity of allergy development.
Area of Science:
- Pediatric Allergy and Immunology
- Environmental Health
- Epidemiology
Background:
- Global rise in sensitization and allergic diseases necessitates understanding contributing factors.
- The
- Aalst Allergy Study
- aimed to assess allergy prevalence and influences in Belgian children.
Purpose of the Study:
- Document prevalences of allergic sensitization and symptoms in a Belgian pediatric cohort.
- Evaluate personal and environmental factors impacting allergy development.
Main Methods:
- Cross-sectional study of 2021 Belgian schoolchildren (3.4–14.8 years).
- Skin prick testing for common aeroallergens.
- Parental questionnaires on allergic symptoms and risk factors.
Main Results:
- Prevalence of sensitization and allergic diseases (eczema, asthma, rhinoconjunctivitis) aligns with literature.
- Significant association between sensitization and allergic symptoms found in children aged 6 years and older.
- Age, gender, BMI, bedroom environment, and pet exposure significantly associated with sensitization and symptoms.
Conclusions:
- Study confirms existing data on allergy and sensitization prevalences.
- Highlights the intricate interplay of factors in allergy development.
- Disease subtypes and factor interactions complicate the understanding of causative elements.
Background:
The prevalence of sensitization and allergic disease has increased significantly worldwide. The aim of the "Aalst Allergy Study" was to document prevalences of sensitization and allergic symptoms, and to evaluate the effect of personal and environmental influences on these prevalences in an unbiased Belgian pediatric population.
Methods:
A cross-sectional study was performed in an unbiased population of 2021 Belgian schoolchildren (3.4-14.8 years). Skin prick testing with the most common aeroallergens was performed. Allergic symptoms as well as potential risk factors for sensitization and allergic disease were documented by a parental questionnaire.
Results:
The prevalence of sensitization to the most common aeroallergens and the prevalence of allergic diseases (eczema, asthma and rhinoconjunctivitis) were in line with the data in the literature. The association of current allergic symptoms with sensitization was only significant in the children aged > or =6 years. Age, gender, body mass index, bedroom environment and exposure to pets were the factors significantly associated with sensitization and allergic symptoms.
Conclusions:
Our study corroborates the reported prevalences of sensitization and allergic diseases. Moreover the study illustrates the complexity of the search for factors involved in the process of sensitization and allergic disease. The impact of different potential causative factors is not only influenced by mutual interactions of these factors, but also by the existence of distinct subtypes of disease.
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