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Peripheral blood stem cell collection in elderly patients.

Adrian Tempescul¹, Jean-Christophe Ianotto, Elisabeth Hardy

¹Department of Clinical Haematology, Institute of Cancerology and Hematology, CHU Morvan, 29609 Brest, France. tempescul@hotmail.com

Annals of Hematology

|August 21, 2009

Summary

Peripheral blood stem cell (PBSC) collection is feasible in patients over 65 years old. This study shows older adults can successfully undergo PBSC harvests, similar to younger individuals, supporting expanded eligibility for intensive treatments.

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Area of Science:

Hematology
Oncology
Transplantation Medicine

Background:

Autologous blood stem cell transplantation is a standard consolidation treatment for lymphoma and myeloma.
The upper age limit for these intensive procedures is increasing.

Purpose of the Study:

To evaluate the feasibility and efficacy of peripheral blood stem cell (PBSC) collection in patients aged 65 years and older.
To compare PBSC harvest outcomes in older patients versus younger patients.

Main Methods:

Retrospective study of 108 patients aged over 65 undergoing PBSC collection over a 7-year period.
Analysis of harvest success rates, number of apheresis procedures, and yield of CD34+ cells/kg.

Main Results:

Successful PBSC harvest was achieved in 100 out of 108 older patients (92.6% success rate).
The majority of patients (71%) required only one apheresis session.
A median yield of 5.3 x 10^6 CD34+ cells/kg was obtained.

Conclusions:

PBSC collection is a feasible and effective procedure in patients over 65 years old.
Older patients can achieve successful stem cell harvests comparable to younger patient populations.
These findings support the expansion of eligibility criteria for autologous stem cell transplantation in older adults.