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Depressive Disorders: Etiology01:27

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A New Method for Inducing a Depression-Like Behavior in Rats
07:57

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Published on: February 22, 2018

PER2 variantion is associated with depression vulnerability.

Catharina Lavebratt1, Louise K Sjöholm1, Timo Partonen2

  • 1Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|August 21, 2009
PubMed
Summary
This summary is machine-generated.

Genetic variations in circadian genes, particularly PER2, are linked to depression vulnerability. This genetic risk for depression may exist independently of environmental stressors like sleep disruption.

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11:31

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Published on: November 30, 2015

Area of Science:

  • Chronobiology
  • Psychiatric Genetics
  • Molecular Psychiatry

Background:

  • Circadian rhythms, regulated by transcription-translation feedback loops, govern daily cycles and are disrupted in depression, often manifesting as sleep disturbances.
  • Genetic variations in core circadian clock genes are hypothesized to contribute to these circadian abnormalities and depression vulnerability.

Purpose of the Study:

  • To investigate the association between genetic variations in core circadian genes and vulnerability to depression.
  • To identify specific circadian genes that may confer genetic risk for depression.

Main Methods:

  • Genotyping of 18 core circadian genes in a Swedish population-based sample.
  • Association testing of genetic variations with depression, including a replication in a second Swedish depression-control sample set.
  • Analysis of potential interactions with environmental factors like negative life events and financial strain.

Main Results:

  • Genetic variation in the PER2 gene was significantly associated with depression vulnerability in a Swedish population.
  • This PER2-associated genetic risk for depression did not appear to be dependent on sleep disturbance factors or other stressors.
  • Polymorphisms in NPAS2, ARNTL, and RORA circadian genes also showed suggestive associations with depression vulnerability, supported by multiple sample sets.

Conclusions:

  • Genetic variation in PER2 is associated with depression vulnerability in a Swedish population.
  • Further research is warranted to confirm the roles of NPAS2, ARNTL, and RORA in depression vulnerability.