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Trypanosoma cruzi-induced suppression of human peripheral blood lymphocytes activated via the alternative (CD2)

L A Beltz1, F Kierszenbaum, M B Sztein

  • 1Department of Microbiology and Public Health, Michigan State University, East Lansing 48824.

Infection and Immunity
|April 1, 1990
PubMed

Coculture of blood forms of Trypanosoma cruzi with human peripheral blood mononuclear cells stimulated with anti-CD2(2) and anti-CD2(3) monoclonal antibodies, i.e., via an antigen-independent pathway of T-lymphocyte activation, resulted in marked immunosuppression compared with that in parallel cultures in which parasites were absent. This effect was evidenced by a decreased lymphoproliferative capacity, a significant reduction in the proportion of cells expressing interleukin-2 receptors, and a significant diminution in the cell surface density of this receptor.

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