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Related Experiment Videos

Plasma catecholamine responses to exercise after training with beta-adrenergic blockade.

E E Wolfel1, W R Hiatt, H L Brammell

  • 1Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 1, 1990
PubMed
Summary

Beta-adrenergic blockade affects how the body adapts to exercise training. Exercise training typically lowers norepinephrine (NE) and epinephrine (EPI), but these changes were blunted by beta-blockers.

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Area of Science:

  • Exercise Physiology
  • Cardiovascular Pharmacology

Background:

  • Exercise training reduces sympathetic nervous system activity, indicated by lower plasma norepinephrine (NE) and epinephrine (EPI).
  • The impact of beta-adrenergic blockade on these exercise-induced adaptations is not fully understood.

Purpose of the Study:

  • To investigate how beta-adrenergic blockade influences the changes in plasma catecholamine levels (NE and EPI) following exercise conditioning.
  • To determine if beta-blockers alter the sympathetic nervous system's adaptation to a 6-week exercise program.

Main Methods:

  • 24 healthy males underwent a 6-week exercise training program.
  • Subjects were randomized to placebo, atenolol, or nadolol groups.
  • Plasma NE and EPI levels were measured at rest and during submaximal and maximal exercise before and after training, with and without medication.

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Main Results:

  • Resting NE and EPI levels did not change post-training in any group.
  • During submaximal exercise, NE decreased with placebo and atenolol but not nadolol; EPI decreased only with placebo.
  • Maximal exercise showed increased NE in all groups post-training; EPI increased with nadolol but not placebo or atenolol.
  • Training-induced catecholamine changes were masked or blunted by beta-blockade.

Conclusions:

  • Beta-adrenergic blockade significantly impacts the sympathetic nervous system's adaptations to exercise training.
  • These effects are particularly noticeable during submaximal exercise, where training-induced reductions in catecholamines are blunted by beta-blockers.