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[Predictive value of Her2/neu expression/amplification for the targeted treatment of breast cancer]

Hans-Anton Lehr1, Stephan C Schaefer, Jean-François Delaloye

  • 1Institut universitaire de pathologie CHUV, Lausanne. hans-anton.lehr@chuv.ch

Revue Medicale Suisse
|August 22, 2009
PubMed

Insights

Testing for Her2/neu overexpression in breast cancer is crucial. This identifies patients who will benefit from targeted antibody therapy, avoiding unnecessary side effects and costs.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Context:

  • Her2/neu receptor tyrosine kinase plays a key role in cell proliferation.
  • Overexpression of Her2/neu is observed in approximately 20% of breast cancer cases.
  • Her2/neu expression correlates with a poor prognosis in breast cancer patients.

Purpose:

  • To discuss methods for detecting Her2/neu overexpression in breast cancer cells.
  • To review current therapeutic strategies targeting Her2/neu.
  • To explore emerging research on novel therapeutic options for Her2/neu-driven cancers.

Summary:

  • Her2/neu overexpression in breast cancer necessitates diagnostic testing for targeted therapy.
  • Anti-Her2/neu antibody treatment is effective only in overexpressing cancers but carries significant side effects and cost.
  • Accurate testing ensures appropriate patient selection for Her2/neu-targeted therapies.

Impact:

  • Facilitates personalized medicine approaches in breast cancer treatment.
  • Improves patient outcomes by enabling targeted therapy selection.
  • Drives research into more effective and safer therapeutic interventions for Her2/neu-positive breast cancers.

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