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Synthesis of functionalized isoquinolines via sequential cyclization/cross-coupling reactions

Xingxin Yu1, Jie Wu

  • 1Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.

Journal of Combinatorial Chemistry
|August 22, 2009
PubMed
Summary

Copper(II) chloride mediated cyclization of alkynylbenzaldehyde oximes efficiently produces 4-chloroisoquinolines. These intermediates are then functionalized using palladium-catalyzed cross-coupling reactions, yielding diverse isoquinoline derivatives.

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