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Updated: Jun 20, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Cyanoacetamide multicomponent reaction (I): Parallel synthesis of cyanoacetamides
Kan Wang1, Katrina Nguyen, Yijun Huang
1University of Pittsburgh, Drug Discovery Institute, Pittsburgh 15261, Pennsylvania, USA.
Abstract:
Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. However the diversity of these scaffolds is hampered by the low variability of the cyanoacetic acid derivatives in the past. Here we describe valuable protocols for the parallel synthesis of arrays of cyanoacetamides on a multigram scale and involving very convenient work up by simple filtration and washing. Fifty-two products are described, and several applications are indicated. We foresee our protocol and the resulting derivatives to become very valuable to greatly expanding the large MCR scaffold space of cyanoacetic acid derivatives.
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