[Effect of beta-adrenoreceptor blockade on cerebral circulation and extracranial vascular tone]

The influence of anapriline (propranolol) on the cerebral circulation rate, tone of the cerebral and femural vessels, pO2 in the cerebral tissue, was studied. I. v. administration of anapriline decreased the arterial blood pressure. The changes of tone of the vessels are often of the two-phase character: a decrease followed by an increase. The lowering of the arterial pressure is the most probable cause of the lowering cerebral circulation rate. pO2 decreases accordingly to the blood flow. The effect of anapriline was greater in anesthetized animals.