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Superficial leiomyosarcoma: a clinicopathologic review and update
Clarissa T Fauth1, Andrea Kristin Bruecks, Walley Temple
1Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Journal of Cutaneous Pathology
|August 22, 2009
Summary
Superficial leiomyosarcomas (SLMSs) are rare skin tumors. Recognizing specific histological features and avoiding diagnostic pitfalls is crucial for accurate SLMS diagnosis and patient management.
Area of Science:
- Dermatopathology
- Oncology
- Soft Tissue Tumors
Background:
- Superficial leiomyosarcomas (SLMSs) are uncommon malignant soft tissue tumors.
- A review of 25 SLMS cases was conducted to better understand their characteristics.
Purpose of the Study:
- To review the clinicopathologic features of superficial leiomyosarcomas.
- To identify key histological findings and prognostic factors for SLMS.
Main Methods:
- Retrospective review of 25 superficial leiomyosarcoma cases diagnosed between 1990 and 2007.
- Analysis of clinical data and detailed histopathological examination, including immunohistochemistry.
Main Results:
- All patients presented with nodules; tumors were dermal or subcutaneous.
- Positive smooth muscle markers and negative CD117 were noted.
- Epidermal hyperplasia, sclerotic bands, and increasing grade with depth were observed; larger size, high grade, and depth correlated with poor outcomes.
Conclusions:
- SLMSs are rare but significant skin smooth muscle tumors with potentially non-specific clinical presentations.
- Histological features like epidermal hyperplasia and thickened collagen bands are underrecognized.
- Immunohistochemistry aids diagnosis, but CD117 has limited utility; superficial biopsies may lead to underdiagnosis, necessitating caution.
