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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Intima media thickness and endothelial function in chronic hemodialysis patients

Rina Rus1, Jadranka Buturović-Ponikvar

  • 1Department of Pediatric Nephrology, Univerity Medical Center Ljubljana, SI-1000 Ljubljana, Slovenia. rina.rus@guest.arnes.si

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|August 22, 2009
PubMed

Insights

Diabetic and hypertensive hemodialysis patients show impaired vascular function, with age being a key factor. Intensive blood pressure management is recommended for these patients.

Area of Science:

  • Vascular Biology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Endothelial dysfunction and atherosclerosis are common in hemodialysis patients.
  • Diabetes and hypertension are significant risk factors for cardiovascular complications in this population.

Purpose of the Study:

  • To assess intima-media thickness (IMT), flow-mediated dilatation (FMD), and nitroglycerin-mediated dilatation (NMD) in diabetic versus non-diabetic hemodialysis patients.
  • To investigate the impact of cardiovascular risk factors on vascular parameters in hemodialysis patients.

Main Methods:

  • B-mode ultrasonography was used to measure carotid and brachial artery IMT, FMD, and NMD in 58 hemodialysis patients.
  • Vascular measurements were correlated with cardiovascular risk factors including age, diabetes, and hypertension.

Main Results:

  • Diabetic patients exhibited significantly lower FMD and NMD compared to non-diabetic patients.
  • Age showed a positive correlation with IMT and a negative correlation with FMD and NMD across all patients.
  • Hypertension and diabetes were negatively correlated with FMD and NMD, indicating impaired vascular function.

Conclusions:

  • Endothelial and smooth vascular functions are significantly impaired in diabetic and hypertensive hemodialysis patients.
  • Hypertension is an independent risk factor for smooth vascular dysfunction in hemodialysis patients.
  • Intensive antihypertensive treatment is recommended for hypertensive chronic hemodialysis patients to mitigate vascular dysfunction.

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