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Lipid peroxidation associated with successful thrombolysis.
S W Davies1, K Ranjadayalan, D G Wickens
1Newham General Hospital, London, UK.
Lancet (London, England)
|March 31, 1990
Summary
Successful thrombolytic treatment for acute myocardial infarction increased lipid peroxidation markers, indicating free radical activity. This suggests reperfusion injury in patients with open arteries post-treatment.
Area of Science:
- Cardiology
- Biochemistry
- Free Radical Research
Background:
- Acute myocardial infarction (AMI) treatment often involves thrombolysis.
- Reperfusion following successful thrombolysis may cause injury.
- Free radicals are implicated in cellular damage during reperfusion.
Purpose of the Study:
- To investigate free radical activity markers after thrombolytic therapy for AMI.
- To correlate changes in lipid peroxidation with successful reperfusion.
- To provide evidence for reperfusion injury in humans.
Main Methods:
- Assessed thiobarbituric-acid-reactive material (TBA-RM) and lipid isomerisation ratio in 50 AMI patients.
- Blood samples collected pre-streptokinase and 2 hours post-treatment.
- Coronary arteriography performed within 72 hours to assess arterial patency.
Main Results:
- Thiobarbituric-acid-reactive material (TBA-RM) levels increased significantly in patients with patent arteries post-thrombolysis.
- TBA-RM levels decreased in patients with occluded arteries.
- No significant change in the lipid isomerisation ratio was observed.
Conclusions:
- Successful thrombolysis in acute myocardial infarction is associated with increased lipid peroxidation.
- This rise in lipid peroxidation suggests free radical-mediated damage during reperfusion.
- The findings provide indirect evidence of reperfusion injury in humans.