Related Experiment Video
Updated: Jun 20, 2026
Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing
Published on: September 15, 2023
Assessment of preoperative serum prolidase activity in epithelial ovarian cancer
Hakan Camuzcuoglu1, Dagistan Tolga Arioz, Harun Toy
1Faculty of Medicine, Department of Obstetrics and Gynecology, Harran University, Sanliurfa, Turkey. hakancamuzcuoglu@gmail.com
Objective:
Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hydroxyproline and plays a major role in collagen turnover. The aim of this study was to evaluate preoperative serum prolidase activity, total oxidant status (TOS), and total antioxidant capacity (TAC) in patients with newly diagnosed epithelial ovarian cancer (EOC).
Study Design:
Serum prolidase activity, TOS, and TAC were measured spectrophotometrically in both EOC cases (n=28) and controls (n=28).
Results:
Preoperative serum prolidase activity and TOS were significantly higher in patients with EOC compared to controls (p=0.009 and 0.008, respectively), whereas TAC was significantly lower in cases (p<0.001). A significant positive correlation was found between the stage, grade, and CA-125 level of EOC and serum prolidase activity (rho=0.466, p=0.012; rho=0.501, p=0.007; and rho=0.447, p=0.017, respectively) and TOS (rho=0.588, p=0.001; rho=0.412, p=0.029; and rho=0.568, p=0.002, respectively). In contrast, there was a negative correlation between TAC and the stage, grade, and CA-125 level of EOC (rho=-0.555, p=0.002; rho=-0.566, p=0.002; and rho=-0.581, p=0.001, respectively).
Conclusion:
Findings of the present study demonstrate that serum prolidase activity is significantly associated with the stage, tumor grade, and preoperative CA-125 level of EOC.
