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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

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Published on: January 12, 2022

Kininogen in autoimmune uveitis: decrease in peripheral blood stream versus increase in target tissue.

Johanna K Zipplies1, Stefanie M Hauck, Stephanie Schoeffmann

  • 1Institute of Animal Physiology, Department of Veterinary Sciences, Ludwig-Maximilians University, Munich, Germany.

Investigative Ophthalmology & Visual Science
|August 22, 2009
PubMed
Summary
This summary is machine-generated.

Researchers identified key serum protein changes in horses with equine recurrent uveitis (ERU). High-molecular-weight kininogen (HK) was found to be upregulated in affected eyes, suggesting a role in ERU pathogenesis and potential as a biomarker.

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Area of Science:

  • Ophthalmology
  • Immunology
  • Veterinary Medicine

Background:

  • Equine recurrent uveitis (ERU) is a leading cause of blindness in horses.
  • The disease involves T-cell mediated destruction of the retina.
  • Identifying accessible biomarkers for ERU monitoring is crucial.

Purpose of the Study:

  • To identify differentially expressed serum proteins in horses with ERU.
  • To investigate the role of candidate proteins in ocular tissues.
  • To find potential biomarkers for ERU prediction and relapse.

Main Methods:

  • Serum proteomes of ERU horses and controls were analyzed using 2-D DIGE.
  • Differentially expressed proteins were identified via mass spectrometry.
  • Candidate protein expression in retina and vitreous was validated using Western blots and immunohistochemistry.

Main Results:

  • Ten proteins showed differential expression between ERU and control groups.
  • Upregulated proteins included IgM, IgG4 hc, serotransferrin, alpha-2HS-glycoprotein, and complement factor B.
  • Downregulated proteins included albumin, apolipoprotein A-IV and H, IgG5 hc, and high-molecular-weight kininogen (HK).
  • HK was significantly upregulated in the vitreous and retina of affected eyes, coexpressing with VEGF.

Conclusions:

  • High-molecular-weight kininogen (HK) is a potential biomarker for ERU.
  • HK's upregulation in ocular tissues suggests a role in ERU pathogenesis, particularly neovascularization.
  • Further research into HK may elucidate ERU mechanisms and inform therapeutic strategies.